Bone marrow cell cycle markers in inherited bone marrow failure syndromes

被引：12

作者：

Al-Rahawan, Mohamad M. ^{[1
,2
]}

Alter, Blanche P. ^{[1
]}

Bryant, Barbara J. ^{[3
]}

Elghetany, A. Tarek ^{[4
]}

机构：

[1] Natl Canc Inst, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA

[2] Childrens Natl Med Ctr, Washington, DC 20010 USA

[3] NIH, Dept Transfus Med, Bethesda, MD 20892 USA

[4] Univ Texas Galveston, Med Branch, Dept Pathol, Galveston, TX 77550 USA

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 12期

关键词：

Inherited bone marrow failure syndromes; Myelodysplastic syndrome; Acute myeloid leukemia; p53; Ki-67; Survivin;

D O I：

10.1016/j.leukres.2008.05.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with inherited bone marrow failure syndromes (IBMFS) are at increased risk of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), possibly related to cell cycle dysregulation. In a cross-sectional analysis of bone marrow from 77 IBMFS, 71 sporadic conditions (AML, MDS, acquired aplastic anemia) and 22 normal controls we found overexpression of p53 in IBMFS, AML, and MDS; of Ki-67 in IBMFS and AML; and of survivin in IBMFS compared with all other groups. The patterns of expression of cell cycle markers in IBMFS are thus distinct. Longitudinal studies will determine the diagnostic and prognostic significance of these findings. Published by Elsevier Ltd.

引用

页码：1793 / 1799

页数：7

共 21 条

[1] Expression and prognostic significance of survivin in de novo acute myeloid leukaemia [J].

Adida, C ;

Recher, C ;

Raffoux, E ;

Daniel, MT ;

Taksin, AL ;

Rousselot, P ;

Sigaux, F ;

Degos, L ;

Altieri, DC ;

Dombret, H .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (01) :196-203

[2] Expression of the proliferation-associated nuclear protein lNUB-1 and its relationship with microvascular density in bone marrow biopsies of patients with myelodysplastic syndromes [J].

Alexandrakis, MG ;

Passam, FH ;

Kyriakou, DS ;

Dambaki, C ;

Katrinakis, GE ;

Tsirakis, G ;

Konsolas, J ;

Stathopoulos, EN .

JOURNAL OF MOLECULAR HISTOLOGY, 2004, 35 (8-9) :857-863

[3]

Alter Blanche P, 2007, Hematology Am Soc Hematol Educ Program, P29, DOI 10.1182/asheducation-2007.1.29

[4] Bone marrow failure syndromes in children [J].

Alter, BP .

PEDIATRIC CLINICS OF NORTH AMERICA, 2002, 49 (05) :973-+

[5]

Alter BP., 2003, Nathan and Oski's Hematology of Infancy and Childhood, P280

[6] Limited numbers of apoptotic cells in fresh paraffin embedded bone marrow samples of patients with myelodysplastic syndrome [J].

Brada, SJL ;

van de Loosdrecht, AA ;

Koudstaal, J ;

de Wolf, JTM ;

Vellenga, E .

LEUKEMIA RESEARCH, 2004, 28 (09) :921-925

[7] Clonal evolution in marrows of patients with Shwachman-Diamond syndrome: A prospective 5-year follow-up study [J].

Dror, Y ;

Durie, P ;

Ginzberg, H ;

Herman, R ;

Banerjee, A ;

Champagne, M ;

Shannon, K ;

Malkin, D ;

Freedman, MH .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (07) :659-669

[8] Significance of p53 overexpression in bone marrow biopsies from patients with bone marrow failure: aplastic anemia, hypocellular refractory anemia, and hypercellular refractory anemia [J].

Elghetany, MT ;

Vyas, S ;

Yuoh, G .

ANNALS OF HEMATOLOGY, 1998, 77 (06) :261-264

[9]

Elghetany MT, 2002, ARCH PATHOL LAB MED, V126, P452

[10]

Foucar K, 2001, BONE MARROW PATHOLOG

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