Early induction of binucleated cells by ultraviolet A (UVA) radiation:: A possible role of microfilaments

被引：8

作者：

Bånrud, H ^{[1
]}

Moan, J ^{[1
]}

Berg, K ^{[1
]}

机构：

[1] Inst Canc Res, Dept Biophys, N-0310 Oslo, Norway

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1999年 / 70卷 / 02期

关键词：

D O I：

10.1111/j.1751-1097.1999.tb07990.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of UVA (365 nm) radiation on the cellular distribution of F-actin and formation of binucleated cells have been studied using 3T3 Swiss albino mouse fibroblasts and V79 Chinese hamster fibroblasts. Ultraviolet A at biologically relevant fluences was found to disintegrate the actin filaments in the cells shortly (5 min) after irradiation, concomitant with the formation of cells with two nuclei. In 76-100% of the bi- and multinucleated cells the distribution of F-actin was clearly altered. Cells in G(1) phase of the cell cycle were most probably involved in the formation of binucleated cells. The disintegration of F-actin was presumably not due to depolymerization of F-actin to G-actin, as the amount of F-actin in the cells was unaltered after UVA exposure but rather due to direct breakage of the actin filaments. Ultraviolet B (297/302 nm) had mo effect on the cellular distribution of microfilaments, not even at highly lethal fluences.

引用

页码：199 / 205

页数：7

共 28 条

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ANDREEFF M, 1990, FLOW CYTOMETRY SORTI, P697

[2] S-PHASE ARREST AND INDUCTION OF MULTINUCLEATED CELLS AFTER EXPOSURE TO ULTRAVIOLET-RADIATION [J].