Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound.

被引：40

作者：

Armour, DR

Chung, KML

Congreve, M

Evans, B

Guntrip, S

Hubbard, T

Kay, C

Middlemiss, D

Mordaunt, JE

Pegg, NA

Vinader, MV

Ward, P

Watson, SP

机构：

[1] GlaxoWellcome Medicines Res. Centre, Stevenage, Hertfordshire, SG1 2NY, Gunnels Wood Road

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 09期

关键词：

D O I：

10.1016/0960-894X(96)00163-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The medicinal chemistry strategy is described which led to the identification of GR205171, an orally active non-peptide neurokinin-1 receptor antagonist that is the most potent broad-spectrum antiemetic agent reported to date. (C) 1996 Elsevier Science Ltd.

引用

页码：1015 / 1020

页数：6

共 13 条

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