Pathophysiology of immune thrombocytopenic purpura

被引：27

作者：

Beardsley, DS ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA

来源：

BLOOD REVIEWS | 2002年 / 16卷 / 01期

关键词：

immune thrombocytopenia; platelets; autoimmunity; animal model;

D O I：

10.1054/blre.2001.0173

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 195 1, the young hematologist in training, Dr. William Harrington, infused himself with plasma from a patient with immune thrombocytopenic purpura (ITP). He rapidly developed severe, but transient, thrombocytopenia and was at risk for serious hemorrhage. Thus, the humoral autoimmune cause of ITP was established. Since 1953, when Dr. Harrington's in vivo studies ended, in vitro investigations have aimed to determine the molecular and cellular details of immune-mediated platelet destruction. (C) 2002, Elsevier Science Ltd. All rights reserved.

引用

页码：13 / 14

页数：2

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