Presence of the bcr/abl rearrangement in a patient with chronic neutrophilic leukaemia

被引:6
作者
Christopoulos, C
Kottoris, K
Mikraki, V
Anevlavis, E
机构
[1] AGIA OLGA HOSP,DEPT INTERNAL MED 1,ATHENS,GREECE
[2] UNIV ATHENS,SCH MED,CHOREMEION ONCOL RES LAB,GR-11527 ATHENS,GREECE
关键词
chronic neutrophilic leukaemia; myeloproliferative disorders; chronic granulocytic leukaemia; bcr/abl rearrangement; Philadelphia chromosome;
D O I
10.1136/jcp.49.12.1013
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
An 83 year old woman presented with a myeloproliferative disorder involving the myeloid and megakaryocytic lines, and characterised by mature neutrophil leucocytosis. There was a high/normal neutrophil alkaline phosphatase activity and absence of the Philadelphia chromosome, features compatible with a diagnosis of chronic neutrophilic leukaemia (CNL). Southern blot analysis of the patient's DNA revealed the presence of the bcr/abl rearrangement. Combined with a previous report of detection of Ph(1) chromosome in long term bone marrow cultures in a patient with CNL, this finding suggests that the bcr/abl hybrid gene might occasionally result in a myeloproliferative disorder with a phenotype closely resembling that of CNL.
引用
收藏
页码:1013 / 1015
页数:3
相关论文
共 6 条
[1]  
LICHTMAN MA, 1995, HEMATOLOGY, P309
[2]  
SANADA I, 1985, JPN J CLIN ONCOL, V15, P553
[3]   DETECTION OF SPECIFIC SEQUENCES AMONG DNA FRAGMENTS SEPARATED BY GEL-ELECTROPHORESIS [J].
SOUTHERN, EM .
JOURNAL OF MOLECULAR BIOLOGY, 1975, 98 (03) :503-+
[4]  
Virgolini L, 1985, Minerva Med, V76, P1951
[5]   ASPECTS OF SPLENIC HYPOFUNCTION IN OLD-AGE [J].
ZAGO, MA ;
FIGUEIREDO, MS ;
COVAS, DT ;
BOTTURA, C .
KLINISCHE WOCHENSCHRIFT, 1985, 63 (13) :590-592
[6]   CHRONIC NEUTROPHILIC LEUKEMIA - A STUDY OF 4 CASES [J].
ZITTOUN, R ;
REA, D ;
NGOC, LH ;
RAMOND, S .
ANNALS OF HEMATOLOGY, 1994, 68 (02) :55-60