Astrocytes coordinate synaptic networks: Balanced excitation and inhibition

被引：141

作者：

Fellin, Tommaso ^{[1
]}

Pascual, Olivier ^{[1
]}

Haydon, Philip G. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Neurosci, Silvio Conte Ctr Integrat Tripartite Synapse, Philadelphia, PA 19104 USA

来源：

PHYSIOLOGY | 2006年 / 21卷

关键词：

D O I：

10.1152/physiol.00161.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Although neurons are essential for brain function, an emerging alternative view holds that astrocytes, the dominant glial cell type, coordinate synaptic networks. Through the release of glutamate, astrocytes locally excite neurons, and via adenosine, which accumulates due to the hydrolysis of released ATP, astrocytes suppress distant synapses.

引用

页码：208 / 215

页数：8

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