Immune regulation by SLAM family receptors and SAP-related adaptors

被引：178

作者：

Veillette, A

机构：

[1] Clin Res Inst Montreal, Montreal, PQ H2W 1R7, Canada

[2] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

[3] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 01期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1038/nri1761

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The signalling lymphocytic activation molecule ( SLAM) family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SAP, the prototype of the SAP family, is mutated in a human immunodeficiency named X-linked lymphoproliferative (XLP) disease. Recent observations indicate that SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. The latest progress in this field is reviewed here.

引用

收藏

页码：56 / 66

页数：11

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