Control of an outbreak due to an adamantane-resistant strain of influenza A (H3N2) in a chronic care facility

被引:6
作者
Cohen, N. J. [1 ,2 ]
Morita, J. Y. [2 ]
Plate, D. K. [2 ]
Jones, R. C. [2 ]
Simon, M. T. [3 ]
Nawrocki, J. [4 ]
Siston, A. M. [2 ]
Gerber, S. I. [2 ]
机构
[1] Ctr Dis Control & Prevent, Chicago Quarantine Stn, Chicago, IL 60666 USA
[2] Chicago Dept Publ Hlth, Chicago, IL USA
[3] Misericordia Heart Mercy Ctr, Chicago, IL USA
[4] Illinois Dept Publ Hlth, Chicago, IL USA
关键词
D O I
10.1007/s15010-008-7295-9
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Chronic care facility residents are at risk of severe influenza infection and death. Adamantanes have been used by chronic care facilities for influenza A prophylaxis; however, genotypic resistance has altered prophylaxis recommendations. An outbreak of influenza A (H3N2) in a chronic care facility housing neurologically impaired children and young adults and subsequent control measures are described. Patients and Methods: Resident charts were retrospectively reviewed. Isolates were characterized by strain identification and pyrosequencing. Results: Although 95 (97%) of 98 residents had been immunized against influenza at the start of the influenza season, 16 (84%) of 19 case patients were identified on the first floor. However, following implementation of enhanced infection control practices and adamantane prophylaxis, only 10 (13%) of 79 case patients were identified on the second floor. Subsequent pyrosequencing studies revealed a serine to asparagine mutation at position 31 of the M2 protein. Conclusions: Enhanced infection control precautions and adamantane prophylaxis were used to control spread of influenza in a chronic care facility. This outbreak demonstrates the importance of timely and consistent implementation of infection control measures in controlling influenza outbreaks in tong term care facilities and raises questions about a possible rote for adamantanes in preventing transmission of adamantane-resistant influenza A viruses.
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页码:458 / 462
页数:5
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