Association study of APC polymorphisms with colorectal cancer in Han Chinese

被引：6

作者：

Huang, Xiaoye ^{[2
,3
,5
]}

Wang, Yang ^{[2
,5
]}

Yu, Tao ^{[2
,5
]}

Liu, Baocheng ^{[2
,5
]}

Li, Xin ^{[2
,5
]}

Li, Weidong ^{[2
,5
]}

Chen, Shiqing ^{[2
,5
]}

Zhao, Qingzhu ^{[2
,5
]}

Li, Xingwang ^{[2
,5
]}

Yang, Fengping ^{[2
,5
]}

Wang, Quan ^{[1
]}

Wang, Jinfen ^{[7
]}

Xiao, Yanzeng ^{[7
]}

Xu, Yifeng ^{[6
]}

Feng, Guoyin ^{[6
]}

Peng, Zhihai ^{[1
]}

He, Lin ^{[2
,3
,4
,5
]}

He, Guang ^{[2
,3
,5
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Gen Surg, Affiliated Shanghai Peoples Hosp 1, Shanghai 200080, Peoples R China

[2] Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China

[3] Shanghai GenomePilot Inst Genom & Human Hlth, Shanghai 200030, Peoples R China

[4] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

[5] Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

[6] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China

[7] Shanxi Canc Hosp, Taiyuan 320013, Peoples R China

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 18期

关键词：

Association; APC gene; Colorectal cancer; Chinese Han population; TUMOR-SUPPRESSOR; RISK; GENES; ADENOMAS; INSIGHTS; DISEASE; LOCUS; FIBER; FAT;

D O I：

10.1016/j.clinbiochem.2012.07.001

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Objectives: Colorectal cancer (CRC) is a common malignancy with worldwide prevalence. Familial adenomatous polyposis (FAP), a predisposition syndrome of CRC, is caused by germ line mutations in the APC gene. Mutations in APC are thought to be an early event in colorectal tumorigenesis. We hypothesized that common variants in APC might be associated with CRC. Design and methods: A case-control study genotyping ten SNPs was conducted in 312 CRC patients and 270 normal controls in the Chinese Han population. Results: The genotype frequency of rs2019720 showed a significant difference between cases and controls (p=0.046. after Bonferroni correction). For the three pairs of SNPs in strong LD, we carried out haplotype analyses but no significant association was detected. Conclusion: Our results suggest that APC polymorphisms might be associated with CRC in the Chinese Han population. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1669 / 1672

页数：4

共 34 条

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