Transfer from manual to automated sample preparation: a case study

被引：14

作者：

Han, SM ^{[1
]}

Munro, A ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Pharmaceut Technol, King Of Prussia, PA 19406 USA

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1999年 / 20卷 / 05期

关键词：

automation; automated sample preparation; assay; Zymark Tablet Processing Work Station (TPW II)(R);

D O I：

10.1016/S0731-7085(99)00078-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A manual sample preparation for a controlled release capsule formulation has been converted to an automated sample preparation. Each step of the manual sample preparation was evaluated as to its feasibility for automation in terms of precision, carryover, filter selection and other critical issues. Although most steps of the manual method were easily translated to the automated procedure, certain 'simple' details such as filter selection, sample storage, and the conversion from volumetric to gravimetric measurements needed closer investigation (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：785 / 790

页数：6