Future directions in myoma research

被引：35

作者：

Brahma, PK ^{[1
]}

Martel, KM ^{[1
]}

Christman, GM ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Obstet & Gynecol, Univ Michigan Hlth Syst, Ann Arbor, MI 48105 USA

来源：

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA | 2006年 / 33卷 / 01期

关键词：

D O I：

10.1016/j.ogc.2005.12.011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This article highlights Our current knowledge of fibroids and addresses future directions for fibroid research and treatment over the next decade. The available data on cytogenetics are discussed, in addition to discoveries into signaling pathways and second messenger molecules in leiomyomas. Current medical management, surgical trends and the barriers to transition to minimally invasive procedures are summarized. Innovations in genetic diagnosis and interventional radiologic-aided therapies may revolutionize therapy for certain populations of patients who have fibroids. From tissue-specific medical management, to minimally invasive surgical techniques, to pharmacogenetics, the Current directions of fibroid research are leading us to an exciting new frontier.

引用

页码：199 / +

页数：27

共 113 条

[1] Abdominal myomectomy: Results of a simple operative technique [J].

Acien, P ;

Quereda, F .

FERTILITY AND STERILITY, 1996, 65 (01) :41-51

[2]

*AG HLTH CAR RES Q, 2001, SUMM EV REP TECHN AS

[3] Gene therapy of uterine leiomyomas: Adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice [J].

Al-Hendy, A ;

Lee, EJ ;

Wang, HQ ;

Copland, JA .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2004, 191 (05) :1621-1631

[4] Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43 [J].

Alam, NA ;

Bevan, S ;

Churchman, M ;

Barclay, E ;

Barker, K ;

Jaeger, EEM ;

Nelson, HM ;

Healy, E ;

Pembroke, AC ;

Friedmann, PS ;

Dalziel, K ;

Calonje, E ;

Anderson, J ;

August, PJ ;

Davies, MG ;

Felix, R ;

Munro, CS ;

Murdoch, M ;

Rendall, J ;

Kennedy, S ;

Leigh, IM ;

Kelsell, DP ;

Tomlinson, IPM ;

Houlston, RS .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (05) :1264-1269

[5] Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency [J].

Alam, NA ;

Rowan, AJ ;

Wortham, NC ;

Pollard, PJ ;

Mitchell, M ;

Tyrer, JP ;

Barclay, E ;

Calonje, E ;

Manek, S ;

Adams, SJ ;

Bowers, PW ;

Burrows, NP ;

Charles-Holmes, R ;

Cook, LJ ;

Daly, BM ;

Ford, GP ;

Fuller, LC ;

Hadfield-Jones, SE ;

Hardwick, N ;

Highet, AS ;

Keefe, M ;

MacDonald-Hull, SP ;

Potts, EDA ;

Crone, M ;

Wilkinson, S ;

Camacho-Martinez, F ;

Jablonska, S ;

Ratnavel, R ;

MacDonald, A ;

Mann, RJ ;

Grice, K ;

Guillet, G ;

Lewis-Jones, MS ;

McGrath, H ;

Seukeran, DC ;

Morrison, PJ ;

Fleming, S ;

Rahman, S ;

Kelsell, D ;

Leigh, I ;

Olpin, S ;

Tomlinson, IPM .

HUMAN MOLECULAR GENETICS, 2003, 12 (11) :1241-1252

[6] ABNORMAL GENE-EXPRESSION IN UTERINE LEIOMYOMAS [J].

ANDERSEN, J ;

BARBIERI, RL .

JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 1995, 2 (05) :663-672

[7] LEIOMYOMA PRIMARY CULTURES HAVE ELEVATED TRANSCRIPTIONAL RESPONSE TO ESTROGEN COMPARED WITH AUTOLOGOUS MYOMETRIAL CULTURES [J].

ANDERSEN, J ;

DYREYES, VM ;

BARBIERI, RL ;

COACHMAN, DM ;

MIKSICEK, RJ .

JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 1995, 2 (03) :542-551

[8] Comparing regulation of the connexin43 gene by estrogen in uterine leiomyoma and pregnancy myometrium [J].

Andersen, J .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2000, 108 :811-815

[9] Gravid uterine rupture after myolysis [J].

Arcangeli, S ;

Pasquarette, MM .

OBSTETRICS AND GYNECOLOGY, 1997, 89 (05) :857-857

[10] Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation [J].

Arici, A ;

Sozen, I .

FERTILITY AND STERILITY, 2000, 73 (05) :1006-1011

← 1 2 3 4 5 6 7 8 9 10 →