Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

被引：58

作者：

Neu-Yilik, G

Gehring, NH

Hentze, MW

Kulozik, AE

机构：

[1] Heidelberg Univ, Dept Pediat Oncol Hematol & Immunol, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, EMBL, Mol Med Partnership Unit, D-69120 Heidelberg, Germany

[3] EMBL Heidelberg, Gene Express Programme, D-69117 Heidelberg, Germany

来源：

GENOME BIOLOGY | 2004年 / 5卷 / 04期

关键词：

D O I：

10.1186/gb-2004-5-4-218

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.

引用

收藏

页数：4

相关论文

共 25 条

[1]

[Anonymous], NCBI Reference Sequence Database

[2]

Bamber BA, 1999, J NEUROSCI, V19, P5348

[3] A splicing-dependent regulatory mechanism that detects translation signals [J].

Carter, MS ;

Li, SL ;

Wilkinson, MF .

EMBO JOURNAL, 1996, 15 (21) :5965-5975

[4] mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae [J].

Dahlseid, JN ;

Lew-Smith, J ;

Lelivelt, MJ ;

Enomoto, S ;

Ford, A ;

Desruisseaux, M ;

McClellan, M ;

Lue, N ;

Culbertson, MR ;

Berman, J .

EUKARYOTIC CELL, 2003, 2 (01) :134-142

[5] Competing functions encoded in the allergy-associated FcεRIβ gene [J].

Donnadieu, E ;

Jouvin, MH ;

Rana, S ;

Moffatt, MF ;

Mockford, EH ;

Cookson, WO ;

Kinet, JP .

IMMUNITY, 2003, 18 (05) :665-674

[6] Noncoding RNA genes [J].

Eddy, SR .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (06) :695-699

[7] Telomere cap components influence the rate of senescence in telomerase-deficient yeast cells [J].

Enomoto, S ;

Glowczewski, L ;

Lew-Smith, J ;

Berman, JG .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (02) :837-845

[8] Nonsense-mediated mRNA decay in Drosophila:: at the intersection of the yeast and mammalian pathways [J].

Gatfield, D ;

Unterholzner, L ;

Ciccarelli, FD ;

Bork, P ;

Izaurralde, E .

EMBO JOURNAL, 2003, 22 (15) :3960-3970

[9] Nonsense-mediated mRNA decay in Saccharomyces cerevisiae [J].

González, CI ;

Bhattacharya, A ;

Wang, WR ;

Peltz, SW .

GENE, 2001, 274 (1-2) :15-25

[10] Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes [J].

Green, Richard E. ;

Lewis, Benjamin P. ;

Hillman, R. Tyler ;

Blanchette, Marco ;

Lareau, Liana F. ;

Garnett, Aaron T. ;

Rio, Donald C. ;

Brenner, Steven E. .

BIOINFORMATICS, 2003, 19 :i118-i121