Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones

被引：64

作者：

Beer, Philip A. ^{[2
]}

Jones, Amy V. ^{[3
]}

Bench, Anthony J. ^{[2
]}

Goday-Fernandez, Andrea ^{[2
]}

Boyd, Elaine M. ^{[2
]}

Vaghela, Krishna J. ^{[2
]}

Erber, Wendy N. ^{[2
]}

Odeh, Bassam ^{[4
]}

Wright, Christine ^{[4
]}

McMullin, Mary Frances ^{[5
]}

Cullis, Jonathan ^{[6
]}

Huntly, Brian J. P. ^{[2
]}

Harrison, Claire N. ^{[7
]}

Cross, Nicholas C. P. ^{[3
]}

Green, Anthony R. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Cambridge CB2 2XY, England

[2] Addenbrookes Hosp, Dept Haematol, Cambridge CB2 2QQ, England

[3] Univ Southampton, Wessex Reg Genet Lab, Salisbury, Wilts, England

[4] City Hosp, Dept Haematol, Birmingham, W Midlands, England

[5] Belfast City Hosp, Dept Haematol, Belfast BT9 7AD, Antrim, North Ireland

[6] Salisbury NHS Fdn Trust, Dept Haematol, Salisbury, Wilts, England

[7] St Thomas Hosp, Dept Haematol, London SE1 7EH, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2009年 / 144卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

myeloproliferative disorder; cytogenetics; clonality; leukaemia; tyrosine kinases; CHRONIC MYELOID-LEUKEMIA; POLYCYTHEMIA-VERA; ESSENTIAL THROMBOCYTHEMIA; MUTATION; DISORDERS; JAK2; HETEROGENEITY; DISEASE; CANCER;

D O I：

10.1111/j.1365-2141.2008.07560.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.

引用

页码：904 / 908

页数：5

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