Immunogenic glycoconjugates implicated in parasitic nematode diseases

被引:69
作者
Dell, A [1 ]
Haslam, SM
Morris, HR
Khoo, KH
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AZ, England
[2] Acad Sinica, Inst Biol Chem, Taipei, Taiwan
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1999年 / 1455卷 / 2-3期
基金
英国惠康基金;
关键词
nematode; glycoconjugate; antigen; structure;
D O I
10.1016/S0925-4439(99)00064-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Parasitic nematodes infect billions of people world-wide, often causing chronic infections associated with high morbidity. The greatest interface between the parasite and its host is the cuticle surface, the outer layer of which in many species is covered by a carbohydrate-rich glycocalyx or cuticle surface coat. In addition many nematodes excrete or secrete antigenic glycoconjugates (ES antigens) which can either help to form the glycocalyx or dissipate more extensively into the nematode's environment. The glycocalyx and ES antigens represent the main immunogenic challenge to the host and could therefore be crucial in determining if successful parasitism is established. This review focuses on a few selected model systems where detailed structural data on glycoconjugates have been obtained over the last few years and where this structural information is starting to provide insight into possible molecular functions. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:353 / 362
页数:10
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