Cardiac troponin I should replace CKMB for the diagnosis of acute myocardial infarction

被引:16
作者
Bhagat, CI [1 ]
Langton, P [1 ]
Lewer, M [1 ]
Ching, S [1 ]
Beilby, JP [1 ]
机构
[1] SIR CHARLES GAIRDNER HOSP,QUEEN ELIZABETH II MED CTR,NEDLANDS,WA 6009,AUSTRALIA
关键词
skeletal muscle damage; marathon runners; creatine kinase MB isoenzyme;
D O I
10.1177/000456329703400503
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Cardiac troponin I (cTnI) has been reported to be a highly specific marker for cardiac injury. We investigated the performance of this assay in patients admitted to a coronary care unit for suspected acute myocardial infarction (AMI), patients with extensive skeletal muscle damage, marathon runners and as a routine diagnostic test over a four week period. cTnI proved to be as sensitive a marker for AMI as creatine kinase/MB isoenzyme (CKMB) in patients admitted to the coronary care unit. In 10 patients with a proven AMI, the cTnI remained elevated from 69 to 183h with a median time of 127h. Cardiac troponin I had superior specificity to CKMB in patients with skeletal muscle damage. It was very useful in these patients to confirm or exclude concurrent myocardial damage. In routine diagnostic use, cTnI had greater efficiency than CKMB to classify patients as having an AMI. Consequently cTnI should replace CKMB as a marker for AMI.
引用
收藏
页码:511 / 516
页数:6
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