Higher lipoprotein-associated phospholipase A2 levels are associated with coronary atherosclerosis documented by coronary angiography

被引：9

作者：

Dohi, Tomotaka ^{[1
]}

Miyauchi, Katsumi ^{[1
]}

Ohkawa, Ryunosuke ^{[2
]}

Nakamura, Kazuhiro ^{[2
]}

Thuboi, Shuta ^{[1
]}

Ogita, Manabu ^{[1
]}

Miyazaki, Tadashi ^{[1
]}

Nishino, Akihisa ^{[1
]}

Yokoyama, Ken ^{[1
]}

Kurata, Takeshi ^{[1
]}

Yatomi, Yutaka ^{[2
]}

Daida, Hiroyuki ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Clin Lab Med, Tokyo 1138655, Japan

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 2012年 / 49卷

关键词：

ACTIVATING-FACTOR ACETYLHYDROLASE; C-REACTIVE PROTEIN; HOMOCYSTEINE THIOLACTONASE ACTIVITY; ELEVATION MYOCARDIAL-INFARCTION; LOW-DENSITY-LIPOPROTEIN; MIDDLE-AGED MEN; ENDOTHELIAL DYSFUNCTION; AMERICAN-COLLEGE; ARTERY-DISEASE; RISK-FACTORS;

D O I：

10.1258/acb.2012.011252

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been proposed as an inflammatory marker of cardiovascular disease. The present study investigates associations between Lp-PLA2 and other important biomarkers in Japanese patients with coronary artery disease. Methods: We measured Lp-PLA2 levels in 141 consecutive patients (age 62.6 +/- 3.8 years; men 69.2%) with angiographic evidence of coronary artery disease (acute coronary syndrome [ACS]; n = 38), stable angina pectoris (SAP; n = 72) or with angiographically normal coronary arteries (NCA; n = 31). Results: Levels of Lp-PLA2 significantly correlated with low-density lipoprotein-cholesterol (r = 0.302), homocysteine (r = 0.528) and paraoxonase (r = 0.401) in all patients (all P < 0.01). Levels of Lp-PLA2 were significantly higher in patients with coronary atherosclerosis (ACS and SAP) than with NCA (P < 0.05). Levels of highly sensitive C-reactive protein were significantly higher in patients with ACS than with SAP and NCA (both P < 0.05). Multivariate logistic regression analyses revealed that higher Lp-PLA2 levels were independently associated with coronary atherosclerosis (odds ratio: 1.058; 95% confidence interval: 1.012-1.121; P = 0.001). Conclusions: Higher Lp-PLA2 levels are associated with coronary atherosclerosis independently of traditional coronary risk factors. Thus, Lp-PLA2 is a novel biomarker of coronary atherosclerosis in Japanese patients. Ann Clin Biochem 2012; 49: 527-533. DOI: 10.1258/acb.2012.011252

引用

页码：527 / 533

页数：7

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