Hepatoprotective effect of the fractions of Ban-zhi-lian on experimental liver injuries in rats

被引：39

作者：

Lin, CC ^{[1
]}

Shieh, DE ^{[1
]}

Yen, MH ^{[1
]}

机构：

[1] TAJEN JR COLL PHARM, DEPT PHARM, PINGTUNG, TAIWAN

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1997年 / 56卷 / 03期

关键词：

Scutellaria rivularis; hepatoprotective; carbon tetrachloride; D-galactosamine; acetaminophen;

D O I：

10.1016/S0378-8741(97)00026-3

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The hepatoprotective effect of various fractions (n-hexane, CHCl3, EtOAc, n-BuOH, and H2O) of Ban-zhi-lian derived from Scutellaria rivularis Benth. was studied against carbon tetrachloride (CCl4), D-galactosamine (D-GalN) and acetaminophen (APAP)-induced acute hepatotoxicity in rats. Liver damage was assessed by quantifying serum activities of glutamate oxaloacetate transaminase (sGOT) and glutamate pyruvate transaminase (sGPT), as well as by histopathological examination. The results indicated that the CHCl3 fraction and EtOAc fractions exhibited the greatest hepatoprotective effects on CCl4-induced liver injuries, the CHCl3 fraction and n-hexane fraction are most potent against D-GalN-induced intoxication, and the CHCl3 fraction represented the most liver-protective effect on APAP-induced hepatotoxicity. The pathological changes of hepatic lesions caused by these three hepatotoxicants were improved by treatment with the fractions mentioned above, which were compared to Glycyrrhizin (GLZ) and Silymarin as standard reference medicines. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：193 / 200

页数：8

共 25 条

[1] THE PHARMACOLOGICAL AND PATHOLOGICAL-STUDIES ON SEVERAL HEPATIC PROTECTIVE CRUDE DRUGS FROM TAIWAN .1. [J].