One-pot preparation of chiral β-amino esters by rhodium-catalyzed three-components coupling reaction

被引：48

作者：

Honda, T ^{[1
]}

Wakabayashi, H ^{[1
]}

Kanai, K ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 02期

关键词：

chiral beta-amino ester; reformatsky reaction; rhodium-catalyzed coupling reaction; Wilkinson's catalyst; diethylzinc;

D O I：

10.1248/cpb.50.307

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chiral beta-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatasky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imine prepared in situ.

引用

页码：307 / 308

页数：2

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