Cardiovascular drug prescriptions and risk of depression in diabetic patients

被引:32
作者
Rathmann, W
Haastert, B
Roseman, JM
Giani, G
机构
[1] Univ Dusseldorf, Diabet Res Inst, Dept Biometr & Epidemiol, MSPH, D-40225 Dusseldorf, Germany
[2] Univ Alabama, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA
关键词
cardiovascular drugs; depression; diabetes mellitus; drug prescription; calcium channel blocker; beta-blocker;
D O I
10.1016/S0895-4356(99)00082-7
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Our aim was to investigate the association of calcium channel blocker (CCB), beta-blocker, and ACE inhibitor medications with the risk of depression in diabetic patients. A case control study was performed using an automated database (MediPlus, IMS) of 400 primary care practices in Germany including 912 diabetic cases with newly diagnosed depression in 1996 (index date) and 912 diabetic controls, matched for age, sex, and index date. The odds ratios (95%-confidence intervals) for depression, adjusted for type of practice, number of Visits and prescriptions, hospitalization, cardiovascular diagnoses, and renal failure, were 2.2 (95% CI: 1.2-4.2) for exposure to CCB 6 months prior to index date, 2.6 (95% CI: 1.1-7.0) for beta-blockers, and 1.3 (95% CI: 0.8-2.2) for ACE inhibitors, respectively. Adjusted odds ratio for CCB (4.3; 95% CI: 1.7-13.5) and beta-blockers (4.5; 95% CI: 1.2-29.5) were higher with daily dosages above the median. Prescriptions of CCB and beta-blockers among diabetic patients may increase the risk of depression Because this association may alternatively be explained by cardiovascular comorbidity, further studies will be necessary to investigate the link between these cardiovascular medications and depression. J CLIN EPIDEMIOL 52;11:1103-1109, 1999 (C) 1999 Elsevier Science Inc.
引用
收藏
页码:1103 / 1109
页数:7
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