Novel model peptide for Atx1-like metallochaperones

被引：51

作者：

Sénèque, O

Crouzy, S

Boturyn, D

Dumy, P

Ferrand, M

Delangle, P

机构：

[1] CEA Grenoble, CEA DSM DRFMC, SCIB, Lab Reconnaissance Ion, F-38054 Grenoble 9, France

[2] CEA Grenoble, CEA DSV DRDC, UMR 5090, Lab Biophys Mol & Cellulaire, F-38054 Grenoble 9, France

[3] Univ Grenoble 1, Etud Dynam & Struct Select Lab, UMR 5616, F-38041 Grenoble 9, France

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 07期

关键词：

D O I：

10.1039/b315489k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The novel cyclodecapeptide c(GMTCSGCSRP) is able to bind soft metals with a selectivity for Hg2+ and Cu+ over Pb2+, Cd2+ and Zn2+, and is demonstrated to be an excellent structural model of the binding loop of the copper metallochaperone Atx1 in its apo and mercury loaded forms.

引用

收藏

页码：770 / 771

页数：2

相关论文

共 15 条

[1] Metallochaperones and metal-transporting ATPases: A comparative analysis of sequences and structures [J].

Arnesano, F ;

Banci, L ;

Bertini, I ;

Ciofi-Baffoni, S ;

Molteni, E ;

Huffman, DL ;

O'Halloran, TV .

GENOME RESEARCH, 2002, 12 (02) :255-271

[2] Solution structure of the Cu(I) and Apo forms of the yeast metallochaperone, Atx1 [J].

Arnesano, F ;

Banci, L ;

Bertini, I ;

Huffman, DL ;

O'Halloran, TV .

BIOCHEMISTRY, 2001, 40 (06) :1528-1539

[3]

BRUNGER AT, 1992, XPLOR VERSION 3 1 SY

[4] Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR [J].

Changela, A ;

Chen, K ;

Xue, Y ;

Holschen, J ;

Outten, CE ;

O'Halloran, TV ;

Mondragón, A .

SCIENCE, 2003, 301 (5638) :1383-1387

[5] Selectivity in heavy metal-binding to peptides and proteins [J].

DeSilva, TM ;

Veglia, G ;

Porcelli, F ;

Prantner, AM ;

Opella, SJ .

BIOPOLYMERS, 2002, 64 (04) :189-197

[6] Transition metal speciation in the cell: Insights from the chemistry of metal ion receptors [J].

Finney, LA ;

O'Halloran, TV .

SCIENCE, 2003, 300 (5621) :931-936

[7]

ORTEGA M, MPV3D PROGRAM STUDY

[8]

PUFHAL RA, 1997, SCIENCE, V278, P853

[9] Crystal structure of the Atx1 metallochaperone protein at 1.02 Å resolution [J].

Rosenzweig, AC ;

Huffman, DL ;

Hou, MY ;

Wernimont, AK ;

Pufahl, RA ;

O'Halloran, TV .

STRUCTURE, 1999, 7 (06) :605-617

[10] Copper delivery by metallochaperone proteins [J].

Rosenzweig, AC .

ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (02) :119-128