Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study

被引:734
作者
Ray, JG [1 ]
Vermeulen, MJ
Schull, MJ
Redelmeier, DA
机构
[1] Univ Toronto, St Michaels Hosp, Dept Med, Toronto, ON M5B 1W8, Canada
[2] Univ Toronto, St Michaels Hosp, Dept Hlth Policy Management & Evaluat, Toronto, ON M5B 1W8, Canada
[3] Univ Toronto, St Michaels Hosp, Dept Obstet & Gynecol, Toronto, ON M5B 1W8, Canada
[4] Univ Toronto, St Michaels Hosp, Div Endocrinol & Metab, Toronto, ON M5B 1W8, Canada
[5] Univ Toronto, Inst Clin Evaluat Sci, Sunnybrook & Womens Coll Hlth Sci Ctr, Dept Med, Toronto, ON, Canada
[6] Univ Toronto, Inst Clin Evaluat Sci, Sunnybrook & Womens Coll Hlth Sci Ctr, Dept Hlth Policy Management & Evaluat, Toronto, ON, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1016/S0140-6736(05)67726-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Maternal placental syndromes, including the hypertensive disorders of pregnancy and abruption or infarction of the placenta, probably originate from diseased placental vessels. The syndromes arise most often in women who have metabolic risk factors for cardiovascular disease, including obesity, pre-pregnancy hypertension, diabetes mellitus, and dyslipidaemia. Our aim was to assess the risk of premature vascular disease in women who had had a pregnancy affected by maternal placental syndromes. Methods We did a population-based retrospective cohort study in Ontario, Canada, of 1.03 million women who were free from cardiovascular disease before their first documented delivery. We defined the following as maternal placental syndromes: pre-eclampsia, gestational hypertension, placental abruption, and placental infarction. Our primary endpoint was a composite of cardiovascular disease, defined as hospital admission or revascularisation for coronary artery, cerebrovascular, or peripheral artery disease at least 90 days after the delivery discharge date. Findings The mean (SD) age of participants was 28.2 (5.5) years at the index delivery, and 75 380 (7%) women were diagnosed with a maternal placental syndrome. The incidence of cardiovascular disease was 500 per million person-years in women who had had a maternal placental syndrome compared with 200 per million in women who had not (adjusted hazard ratio [HR] 2.0, 95 CI 1.7-2.2). This risk was higher in the combined presence of a maternal placental syndrome and poor fetal growth (3.1, 2.2-4.5) or a maternal placental syndrome and intrauterine fetal death (4.4, 2.4-7.9), relative to neither. Interpretation The risk of premature cardiovascular disease is higher after a maternal placental syndrome, especially in the presence of fetal compromise. Affected women should have their blood pressure and weight assessed about 6 months postpartum, and a healthy lifestyle should be emphasised.
引用
收藏
页码:1797 / 1803
页数:7
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