A complex barcode underlies the heterogeneous response of p53 to stress

被引：341

作者：

Murray-Zmijewski, Fiona ^{[1
]}

Slee, Elizabeth A. ^{[1
]}

Lu, Xin ^{[1
]}

机构：

[1] Univ Oxford, Ludwig Inst Canc Res Ltd, Nuffield Dept Clin Med, Oxford OX3 7DQ, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 09期

关键词：

D O I：

10.1038/nrm2451

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by way of post-translational modifications and interactions with cofactors. The precise combination of these marks, much like the bars in a barcode, dictates the behaviour of p53 in any given situation.

引用

页码：702 / 712

页数：11

共 107 条

[1] A comprehensive study of p53 transcriptional activity in thymus and spleen of γ irradiated mouse:: High sensitivity of genes involved in the two main apoptotic pathways [J].

Alvarez, Sandra ;

Drane, Pascal ;

Meiller, Anne ;

Bras, Marlene ;

Deguin-Chambon, Valerie ;

Bouvard, Veronique ;

May, Evelyne .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2006, 82 (11) :761-770

[2] Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma [J].

Amaravadi, Ravi K. ;

Yu, Duonan ;

Lum, Julian J. ;

Bui, Thi ;

Christophorou, Maria A. ;

Evan, Gerard I. ;

Thomas-Tikhonenko, Andrei ;

Thompson, Craig B. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (02) :326-336

[3] Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function [J].

Andrews, P. ;

He, Y. J. ;

Xiong, Y. .

ONCOGENE, 2006, 25 (33) :4534-4548

[4] p53: new roles in metabolism [J].

Bensaad, Karim ;

Vousden, Karen H. .

TRENDS IN CELL BIOLOGY, 2007, 17 (06) :286-291

[5] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[6] iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human [J].

Bergamaschi, D ;

Samuels, Y ;

O'Neil, NJ ;

Trigiante, G ;

Crook, T ;

Hsieh, JK ;

O'Connor, DJ ;

Zhong, S ;

Campargue, I ;

Tomlinson, ML ;

Kuwabara, PE ;

Lu, X .

NATURE GENETICS, 2003, 33 (02) :162-167

[7] Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice [J].

Bouvard, V ;

Zaitchouk, T ;

Vacher, M ;

Duthu, A ;

Canivet, M ;

Choisy-Rossi, C ;

Nieruchalski, M ;

May, E .

ONCOGENE, 2000, 19 (05) :649-660

[8] p53 ubiquitination: Mdm2 and beyond [J].

Brooks, CL ;

Gu, W .

MOLECULAR CELL, 2006, 21 (03) :307-315

[9] Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression [J].

Budhram-Mahadeo, Vishwanie S. ;

Bowen, Samantha ;

Lee, Sonia ;

Perez-Sanchez, Christina ;

Ensor, Elizabeth ;

Morris, Peter J. ;

Latchman, David S. .

NUCLEIC ACIDS RESEARCH, 2006, 34 (22) :6640-6652

[10] The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21CIP1/Waf1 [J].

Budram-Mahadeo, V ;

Morris, PJ ;

Latchman, DS .

ONCOGENE, 2002, 21 (39) :6123-6131

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