Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States:: Results from the TRUST Surveillance Program, 1999-2000

被引：137

作者：

Thornsberry, C

Sahm, DF

Kelly, LJ

Critchley, IA

Jones, ME

Evangelista, AT

Karlowsky, JA

机构：

[1] Focus Technol Inc, Herndon, VA 20171 USA

[2] Focus Technol Inc, Nashville, TN USA

[3] Focus Technol Inc, Hilversum, Netherlands

[4] Ortho McNeill Pharmaceut Inc, Raritan, NJ USA

来源：

CLINICAL INFECTIOUS DISEASES | 2002年 / 34卷

关键词：

D O I：

10.1086/324525

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ongoing TRUST (Tracking Resistance in the United States Today) study, which began monitoring antimicrobial resistance among respiratory pathogens in 1996, routinely tracks resistance at national and regional levels. The 1999-2000 TRUST study analyzed 9499 Streptococcus pneumoniae, 1934 Haemophilus influenzae, and 1108 Moraxella catarrhalis isolates that were prospectively collected from 239 laboratories across the 9 US Bureau of the Census regions. Penicillin-resistant S. pneumoniae varied significantly by region, from 8.3% to 24.8% (P<.001). In each region, penicillin resistance closely predicted resistance to other β-lactams, macrolides, and trimethoprim-sulfamethoxazole. Levofloxacin resistance was 0.5% nationally (regional range, 0.1%-1.0%). Multidrug resistance also varied significantly (P<.001) by region. beta-Lactamase production among H. influenzae varied significantly (regional range, 24.0%-34.6%) and M. catarrhalis (86.2%-96.8%) also varied by region. Notable variation in regional antimicrobial resistance rates (S. pneumoniae) and beta-lactamase production (H. influenzae, M. catarrhalis) exists throughout the United States.

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页码：S4 / S16

页数：13

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