3D-printed devices for continuous-flow organic chemistry

被引：140

作者：

Dragone, Vincenza ^{[1
]}

Sans, Victor ^{[1
]}

Rosnes, Mali H. ^{[1
]}

Kitson, Philip J. ^{[1
]}

Cronin, Leroy ^{[1
]}

机构：

[1] Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 9卷

基金：

英国工程与自然科学研究理事会;

关键词：

3D printing; flow chemistry; flow IR; in-line analysis; imine reduction; imine synthesis; millifluidics; reactionware; LINE IR-ANALYSIS; REACTION OPTIMIZATION; NMR; MICROREACTORS; REACTIONWARE; REACTORS; SYSTEM; CHIP; CELL; TOOL;

D O I：

10.3762/bjoc.9.109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present a study in which the versatility of 3D-printing is combined with the processing advantages of flow chemistry for the synthesis of organic compounds. Robust and inexpensive 3D-printed reactionware devices are easily connected using standard fittings resulting in complex, custom-made flow systems, including multiple reactors in a series with in-line, real-time analysis using an ATR-IR flow cell. As a proof of concept, we utilized two types of organic reactions, imine syntheses and imine reductions, to show how different reactor configurations and substrates give different products.

引用

页码：951 / 959

页数：9

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