Supramammillary and adjacent nuclei lesions impair spatial working memory and induce anxiolitic-like behavior

被引:35
作者
Aranda, L
Santín, LJ
Begega, A
Aguirre, JA
Arias, JL
机构
[1] Univ Malaga, Fac Psicol, Dpto Psicobiol & Metodol CC, E-29071 Malaga, Spain
[2] Univ Oviedo, Lab Psicobiol, Oviedo, Spain
[3] Univ Malaga, Dpto Fisiol Humana, Malaga, Spain
关键词
spatial learning; mammillary region; electrolytic lesion; Sprague-Dawley rats;
D O I
10.1016/j.bbr.2005.09.002
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The present study assesses the involvement of the supramammillary and adjacent nuclei in spatial memory and anxiety-like behaviors. Rats with electrolytic lesions in the supramammillary nucleus were pre- and post-operatively trained in two spatial memory tasks and two anxiety tasks. Spatial memory tasks were performed in an open field with seven different goal positions containing the reward. Anxiety-like behaviors were tested in the elevated T-maze. In the spatial reference memory task, neither lesioned nor sham-lesioned groups were impaired. In the working memory task, lesioned animals were permanently impaired in their ability to solve the delayed-matching-to-position task. This working memory deficit is not related to increased proactive interference. It could be related to impairment of the rats ability to reorganize spatial stimuli. Consequently, rats were not able to achieve an optimal performance level to solve spatial tasks with continuous changes in the place location. In the elevated T-maze, lesioned rats reduced passive avoidance response but no changes in the escape response were observed. These results suggest a clear involvement of the supramammillary nucleus in working memory and behavioral inhibition but not in either spatial reference memory or in escape responses. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:156 / 164
页数:9
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