A Brain-Wide Study of Age-Related Changes in Functional Connectivity

被引：544

作者：

Geerligs, Linda ^{[1
,2
]}

Renken, Remco J. ^{[2
]}

Saliasi, Emi ^{[2
,3
]}

Maurits, Natasha M. ^{[2
,3
]}

Lorist, Monicque M. ^{[1
,2
]}

机构：

[1] Univ Groningen, Fac Behav & Social Sci, Dept Expt Psychol, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Neuroimaging Ctr, Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands

来源：

CEREBRAL CORTEX | 2015年 / 25卷 / 07期

关键词：

aging; dedifferentiation; fMRI; functional connectivity; graph theory; INDIVIDUAL-DIFFERENCES; MODULAR ORGANIZATION; COMMUNITY STRUCTURE; DEFAULT NETWORK; GLOBAL SIGNAL; STATE; FLUCTUATIONS; ECONOMY; ADULTS; MODE;

D O I：

10.1093/cercor/bhu012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aging affects functional connectivity between brain areas, however, a complete picture of how aging affects integration of information within and between functional networks is missing. We used complex network measures, derived from a brain-wide graph, to provide a comprehensive overview of age-related changes in functional connectivity. Functional connectivity in young and older participants was assessed during resting-state fMRI. The results show that aging has a large impact, not only on connectivity within functional networks but also on connectivity between the different functional networks in the brain. Brain networks in the elderly showed decreased modularity (less distinct functional networks) and decreased local efficiency. Connectivity decreased with age within networks supporting higher level cognitive functions, that is, within the default mode, cingulo-opercular and fronto-parietal control networks. Conversely, no changes in connectivity within the somatomotor and visual networks, networks implicated in primary information processing, were observed. Connectivity between these networks even increased with age. A brain-wide analysis approach of functional connectivity in the aging brain thus seems fundamental in understanding how age affects integration of information.

引用

页码：1987 / 1999

页数：13

共 86 条

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