Sugar-installed block copolymer micelles: Their preparation and specific interaction with lectin molecules

被引：140

作者：

Nagasaki, Y

Yasugi, K

Yamamoto, Y

Harada, A

Kataoka, K

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan

[2] Tokyo Univ Sci, Dept Mat Sci, Noda, Chiba 2788510, Japan

来源：

BIOMACROMOLECULES | 2001年 / 2卷 / 04期

关键词：

D O I：

10.1021/bm015574q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several types of sugar-installed poly(ethylene glycol)/poly(DL-lactide) (sugar-PEG/PLA) block copolymers were synthesized. The synthesized block copolymer forms a core-shell type polymeric micelle in aqueous media possessing sugar molecules on its surface. Specific recognition of lectin proteins with the sugar molecules on the micelle surface was observed. Both the galactose- and lactose-installed micelles specifically interacted with RCA-1; on the other hand the mannose-installed micelle interacted specifically with Con A. With a lectin-immobilized affinity column, the cluster effect of the sugar molecule on the micelle surface was clearly observed.

引用

页码：1067 / 1070

页数：4

共 39 条

[1] MECHANISM OF BINDING OF MONO- AND OLIGOSACCHARIDES TO CONCANAVALIN-A - SOLVENT PROTON MAGNETIC-RELAXATION DISPERSION STUDY [J].