Wiring specificity in the olfactory system

被引：64

作者：

Jefferis, GSXE

Hummel, T

机构：

[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

[2] Univ Munster, Inst Neurobiol, D-48149 Munster, Germany

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 01期

基金：

英国惠康基金;

关键词：

wiring specificity; olfactory receptor neurons; olfactory projection neurons; glomerulus; antennal lobe;

D O I：

10.1016/j.semcdb.2005.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The fruitfly brain learns about the olfactory world by reading the activity of about 50 distinct channels of incoming information. The receptor neurons that compose each channel have their own distinctive odour response profile governed by a specific receptor molecule. These receptor neurons form highly specific connections in the first olfactory relay of the fly brain, each synapsing with specific second order partner neurons. We use this system to discuss the logic of wiring specificity in the brain and to review the cellular and molecular mechanisms that allow such precise wiring to develop. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：50 / 65

页数：16

共 83 条

[1] Dock and Pak regulate olfactory axon pathfinding in Drosophila [J].