Arginine methylation of hnRNP K enhances p53 transcriptional activity

被引：40

作者：

Chen, Yibin ^{[1
]}

Zhou, Xinyuan ^{[1
]}

Liu, Na ^{[2
,3
]}

Wang, Chaochen ^{[1
]}

Zhang, Liang ^{[1
]}

Mo, Wei ^{[1
]}

Hu, Gengxi ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China

[2] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China

[3] Univ Sci & Technol China, Dept Neurobiol, Sch Life Sci, Hefei, Anhui, Peoples R China

来源：

FEBS LETTERS | 2008年 / 582卷 / 12期

关键词：

hnRNP K; UV radiation; arginine methylation; p53; transcriptional regulation;

D O I：

10.1016/j.febslet.2008.04.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity. (C) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：1761 / 1765

页数：5

共 24 条

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