Enantioselective hydrogenation of pyruvates over polymer-stabilized and supported platinum nanoclusters

被引：131

作者：

Zuo, XB

Liu, HF ^{[1
]}

Guo, DW

Yang, XZ

机构：

[1] Chinese Acad Sci, Polymer Chem Lab, Beijing 100080, Peoples R China

[2] Chinese Acad Sci, China Petrochem Corp, Inst Chem, Beijing 100080, Peoples R China

来源：

TETRAHEDRON | 1999年 / 55卷 / 25期

关键词：

enantioselective hydrogenation; pyruvate; platinum nanocluster; molecular mechanics;

D O I：

10.1016/S0040-4020(99)00415-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cinchonidine-modified enantioselective hydrogenation of pyruvates has been studied over polyvinylpyrrolidone-stabilized platinum (PVP-Pt) and the corresponding alumina-supported platinum (Al2O3-Pt) clusters. It is shown that the catalysts with particle size less than 2.0 nm demonstrate >90% enantioselectivity in favor of (R)-lactates. The solvent effect is similar to that over the conventional supported platinum catalyst except for tetrahydrofuran. These colloidal and supported clusters are stable with no obvious loss of activity and enantioselectivity even after 18 months standing in air at room temperature. Molecular mechanics calculations of the modifier-reactant interaction on the platinum surface suggest that it is possible to obtain good enantioselectivity on the small clusters. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7787 / 7804

页数：18

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[1]

[Anonymous], J CHEM SOC JPN

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