Elevated third-trimester haemoglobin A1c predicts preterm delivery in type 1 diabetes

被引：41

作者：

Ekbom, Pia ^{[1
]}

Damm, Peter ^{[2
]}

Feldt-Rasmussen, Bo ^{[3
]}

Feldt-Rasmussen, Ulla ^{[1
]}

Jensen, Dorte M. ^{[4
]}

Mathiesen, Elisabeth R. ^{[1
]}

机构：

[1] Rigshosp, Natl Univ Hosp, Endocrine Clin, DK-2100 Copenhagen, Denmark

[2] Natl Univ Hosp, Copenhagen & Steno Diabet Ctr, Obstet Clin, Gentofte, Denmark

[3] Natl Univ Hosp, Nephrol Clin, Copenhagen, Denmark

[4] Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense, Denmark

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2008年 / 22卷 / 05期

关键词：

premature labour; glycated haemoglobin; insulin-dependent diabetes mellitus; pregnancy in diabetes; Caucasian race;

D O I：

10.1016/j.jdiacomp.2007.03.008

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The prevalence of preterm delivery is considerably elevated in women with type 1 diabetes. The aim of the study was to evaluate haemoglobin A(1c) (HbA(1c)) as a predictor of preterm delivery. Two hundred thirteen consecutive pregnant women with type 1 diabetes and normal urinary albumin excretion were included prospectively. HbA(1c) was analyzed at 10, 20 and 28 weeks of gestation. Seventy-one women (33%) delivered pre term and 142 at term. At 10 weeks of gestation, HbA(1c) was 7.3% (S.D. 1.0) vs. 6.9% (S.D. 0.9) (P<.01), at 20 weeks of gestation 6.6% (S.D. 0.7) vs. 6.1% (S.D. 0.7) (P<.001) and at 28 weeks of gestation 6.7% (S.D. 0.8) vs. 6.1% (S.D. 0.7) (P<.001). When comparing HbA(1c) at 10, 20 and 28 weeks of gestation, HbA(1c) at 28 weeks of gestation (P<.001) was the best predictor of preterm delivery. The adjusted odds ratio per 1% increment in HbA(1c) at 28 weeks of gestation was 2.8 (95% CI 1.7-4.4). HbA(1c) at 28 weeks of gestation was a clinical significant predictor of preterm delivery in type 1 diabetes. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：297 / 302

页数：6

共 29 条

[1]

Diabet Control Complications Trial Res Grp, 1996, AM J OBSTET GYNECOL, V174, P1343

[2]

Pregnancy outcome in women with insulin-dependent diabetes mellitus complicated by nephropathy [J].

Dunne, FP ;

Chowdhury, TA ;

Hartland, A ;

Smith, T ;

Brydon, PA ;

McConkey, C ;

Nicholson, HO .

QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 1999, 92 (08) :451-454

[3]

Pregnancy outcome in type 1 diabetic women with microalbuminuria [J].

Ekbom, P ;

Damm, P ;

Feldt-Rasmussen, B ;

Feldt-Rasmussen, U ;

Molvig, J ;

Mathiesen, ER .

DIABETES CARE, 2001, 24 (10) :1739-1744

[4]

Risk indicators predictive for severe hypoglycemia during the first trimester of type 1 diabetic pregnancy [J].

Evers, IM ;

van der Schoot, B ;

ter Braak, EWMT ;

Janssen, N ;

de Valk, HW ;

Visser, GHA .

DIABETES CARE, 2002, 25 (03) :554-559

[5]

ENZYME-IMMUNOASSAY - AN IMPROVED DETERMINATION OF URINARY ALBUMIN IN DIABETICS WITH INCIPIENT NEPHROPATHY [J].

FELDTRASMUSSEN, B ;

DINESEN, B ;

DECKERT, M .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1985, 45 (06) :539-544

[6]

OUTCOME OF PREGNANCIES COMPLICATED BY TYPE-1 INSULIN-DEPENDENT DIABETES IN SWEDEN - ACUTE PREGNANCY COMPLICATIONS, NEONATAL-MORTALITY AND MORBIDITY [J].

HANSON, U ;

PERSSON, B .

AMERICAN JOURNAL OF PERINATOLOGY, 1993, 10 (04) :330-333

[7]

Hod M, 1999, J PEDIATR ENDOCR MET, V12, P867

[8]

Outcomes in type 1 diabetic pregnancies - A nationwide, population-based study [J].

Jensen, DM ;

Damm, P ;

Moelsted-Pedersen, L ;

Ovesen, P ;

Westergaard, JG ;

Moeller, M ;

Beck-Nielsen, H .

DIABETES CARE, 2004, 27 (12) :2819-2823

[9]

Do HbA1c levels and the self-monitoring of blood glucose levels adequately reflect glycaemic control during pregnancy in women with type 1 diabetes mellitus? [J].

Kerssen, A ;

de Valk, HW ;

Visser, GHA .

DIABETOLOGIA, 2006, 49 (01) :25-28

[10]

DIABETIC NEPHROPATHY AND PERINATAL OUTCOME [J].

KITZMILLER, JL ;

BROWN, ER ;

PHILLIPPE, M ;

STARK, AR ;

ACKER, D ;

KALDANY, A ;

SINGH, S ;

HARE, JW .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1981, 141 (07) :741-751

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