Polymorphisms of inflammatory markers and risk of essential hypertension in Tatars from Russia

被引：12

作者：

Timasheva, Yanina R. ^{[1
]}

Nasibullin, Timur R. ^{[1
]}

Imaeva, Elvira B. ^{[1
]}

Erdman, Vera V. ^{[1
]}

Kruzliak, Peter ^{[2
,3
]}

Tuktarova, Ilsiyar A. ^{[1
]}

Nikolaeva, Irina E. ^{[4
]}

Mustafina, Olga E. ^{[1
]}

机构：

[1] RAS, Ufa Sci Ctr, Inst Biochem & Genet, Ufa, Russia

[2] St Annes Univ Hosp, Int Clin Res Ctr, Dept Cardiovasc Dis, Brno 65691, Czech Republic

[3] Masaryk Univ, Brno 65691, Czech Republic

[4] St Kuvikina, Republ Ctr Cardiol, Ufa, Russia

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2015年 / 37卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

Adhesion molecules; cytokines; essential hypertension; genetic polymorphism; selectins; Tatars; ENDOTHELIAL GROWTH-FACTOR; CARDIAC OUTCOMES TRIAL; SOLUBLE P-SELECTIN; VASCULAR DYSFUNCTION; BLOOD-PRESSURE; EXPRESSION; SUSCEPTIBILITY; DISEASE; ICAM-1; ATHEROSCLEROSIS;

D O I：

10.3109/10641963.2014.987394

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Essential hypertension (EH) is a common disease with a clear genetic component. Inflammation and endothelial dysfunction play a prominent role in the development of persistent blood pressure elevation. The aim of the current study was to detect an association between EH and polymorphic markers in genes encoding for molecules involved in the control of intercellular interactions during the inflammation process. We analysed SNPs in SELE, SELP, SELL, ICAM1, VEGFA, IL1B, IL6, IL10 and IL12B genes in a group of 534 men of Tatar ethnicity (217 patients with EH and 317 controls). Using a Markov chain Monte-Carlo-based approach (APSampler), we found genotype and allelic combinations associated with EH. The most significant associations were observed for SELE rs2076059*C-SELP rs6131*A-VEGFA -2549*I-IL1B rs16944*C (p = 3.42 x 10(-5), FDR q = 0.035) and SELE rs2076059*C-SELP rs6131*A-IL12B rs3212227*C-IL1B rs16944*C (p = 323 x 10(-4), FDR q = 0.035).

引用

页码：398 / 403

页数：6

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