Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane

被引：335

作者：

Baron, CL ^{[1
]}

Malhotra, V ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol, Sect Cell & Dev Biol, La Jolla, CA 92093 USA

来源：

SCIENCE | 2002年 / 295卷 / 5553期

关键词：

D O I：

10.1126/science.1066759

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Protein kinase D (PKD) is a cytosolic serine-threonine kinase that binds to the trans-Golgi network (TGN) and regulates the fission of transport carriers specifically destined to the cell surface. PKD was found to bind diacylglycerol (DAG), and this binding was necessary for its recruitment to the TGN. Reducing cellular levels of DAG inhibited PKD recruitment and blocked protein transport from the TGN to the cell surface. Thus, a DAG-dependent, PKD-mediated signaling regulates the formation of transport carriers from the TGN in mammalian cells.

引用

页码：325 / 328

页数：4

共 23 条

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