MAPK-regulated transcription: A continuously variable gene switch?

被引：328

作者：

Hazzalin, CA ^{[1
]}

Mahadevan, LC ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Nucl Signalling Lab, Oxford OX1 3QU, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 01期

关键词：

D O I：

10.1038/nrm715

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Switching mechanisms that control genes could be viewed either as stable binary switches, in which genes exist in 'on' or 'off' states; or as quantitative rheostat-like switches, in which the rate of transcription is continuously variable and coupled directly to the strength of intracellular signalling events. Here, we discuss the biological need for quantitative gene regulation and, using mitogen-activated protein kinase (MAPK)-controlled transcription as a model, assess the evidence for its existence and postulate mechanisms by which it might occur.

引用

页码：30 / 40

页数：11

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