Porins in the cell wall of Mycobacterium tuberculosis

被引：57

作者：

Kartmann, B

Stengler, S

Niederweis, M

机构：

[1] Univ Erlangen Nurnberg, Lehrstuhl Mikrobiol, D-91058 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91058 Erlangen, Germany

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 20期

关键词：

D O I：

10.1128/JB.181.20.6543-6546.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lipid bilayer experiments indicated that the cell wall of Mycobacterium tuberculosis contains at least two different porins: (i) a cation-selective, heat-sensitive 0.7-nS channel which has a short-lived open state and is probably composed of 15-kDa subunits and (ii) a 3-nS, >60-kDa channel with a long-lived open state, resembling porins from fast-growing mycobacteria.

引用

收藏

页码：6543 / 6546

页数：4

相关论文

共 20 条

[1] THE ENVELOPE OF MYCOBACTERIA [J].

BRENNAN, PJ ;

NIKAIDO, H .

ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :29-63

[2]

BUCHLER LK, 1991, J BIOL CHEM, V266, P24446

[3]

HEINZ C, UNPUB

[4] PEPTIDOGLYCAN-ASSOCIATED POLYPEPTIDES OF MYCOBACTERIUM-TUBERCULOSIS [J].

HIRSCHFIELD, GR ;

MCNEIL, M ;

BRENNAN, PJ .

JOURNAL OF BACTERIOLOGY, 1990, 172 (02) :1005-1013

[5] PERMEABILITY BARRIER TO HYDROPHILIC SOLUTES IN MYCOBACTERIUM-CHELONEI [J].

JARLIER, V ;

NIKAIDO, H .

JOURNAL OF BACTERIOLOGY, 1990, 172 (03) :1418-1423

[6] CHARACTERIZATION OF THE MAJOR MEMBRANE-PROTEIN OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS [J].

LEE, BY ;

HEFTA, SA ;

BRENNAN, PJ .

INFECTION AND IMMUNITY, 1992, 60 (05) :2066-2074

[7] Biochemical and biophysical characterization of the cell wall porin of Corynebacterium glutamicum:: The channel is formed by a low molecular mass polypeptide [J].

Lichtinger, T ;

Burkovski, A ;

Niederweis, M ;

Krämer, R ;

Benz, R .

BIOCHEMISTRY, 1998, 37 (43) :15024-15032

[8] Voltage-dependent closing of porin channels: Analysis of relaxation kinetics [J].

Mathes, A ;

Engelhardt, H .

JOURNAL OF MEMBRANE BIOLOGY, 1998, 165 (01) :11-18

[9] SILVER STAIN FOR PROTEINS IN POLYACRYLAMIDE GELS - A MODIFIED PROCEDURE WITH ENHANCED UNIFORM SENSITIVITY [J].

MORRISSEY, JH .

ANALYTICAL BIOCHEMISTRY, 1981, 117 (02) :307-310

[10] Cloning of the mspA gene encoding a porin from Mycobacterium smegmatis [J].

Niederweis, M ;

Ehrt, S ;

Heinz, C ;

Klöcker, U ;

Karosi, S ;

Swiderek, KM ;

Riley, LW ;

Benz, R .

MOLECULAR MICROBIOLOGY, 1999, 33 (05) :933-945