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Calorie restriction and sirtuins revisited

被引：339
作者：
Guarente, Leonard [1 ]
机构：
[1] MIT, Dept Biol, Glenn Lab Sci Aging, Cambridge, MA 02139 USA
来源：
GENES & DEVELOPMENT | 2013年 / 27卷 / 19期
关键词：
CR mimetics; calorie restriction; sirtuins; NF-KAPPA-B; FATTY-ACID OXIDATION; LIFE-SPAN EXTENSION; ACTIVATED PROTEIN-KINASE; PANCREATIC BETA-CELLS; STIMULATED INSULIN-SECRETION; HISTONE DEACETYLASE SIRT6; DEPENDENT GENE-EXPRESSION; SMALL-MOLECULE ACTIVATORS; INDUCIBLE FACTOR 1-ALPHA;
D O I：
10.1101/gad.227439.113
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real.
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页码：2072 / 2085
页数：14
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