Quantitative optical imaging of the pharmacokinetics of fluorescent-specific antibodies to tumor markers through tissuelike turbid media

被引：15

作者：

Gannot, I ^{[1
]}

Garashi, A

Chernomordik, V

Gandjbachkhe, A

机构：

[1] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-69978 Tel Aviv, Israel

[2] NICHHD, NIH, Bethesda, MD 20892 USA

来源：

OPTICS LETTERS | 2004年 / 29卷 / 07期

关键词：

D O I：

10.1364/OL.29.000742

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Fluorescent optical imaging of tumors deep within tissue depends on specific binding of antibodies to the tumors' surface markers. These fluorescent antibodies propagating in the vicinity of the tumor can be attached to and (or) diffused away from it. We illustrate application of a new tool, based on the random-walk theory in turbid media, for extracting the pharmacokinetics of these fluorescent antibodies by data deconvolution, excluding the effect of upper turbid tissue layers. (C) 2004 Optical Society of America.

引用

页码：742 / 744

页数：3

共 12 条

[1] Optical-based molecular imaging: contrast agents and potential medical applications [J].

Bremer, C ;

Ntziachristos, V ;

Weissleder, R .

EUROPEAN RADIOLOGY, 2003, 13 (02) :231-243

[2] Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform [J].

Bugaj, JE ;

Achilefu, S ;

Dorshow, RB ;

Rajagopalan, R .

JOURNAL OF BIOMEDICAL OPTICS, 2001, 6 (02) :122-133

[3]

Gandjbakhche A. H., 1995, PROGR OPTICS, P335

[4] Quantitative fluorescent imaging of specific markers of diseased tissue [J].

Gandjbakhche, AH ;

Gannot, I .

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 1996, 2 (04) :914-921

[5] Effects of multiple-passage probabilities on fluorescent signals from biological media [J].

Gandjbakhche, AH ;

Bonner, RF ;

Nossal, R ;

Weiss, GH .

APPLIED OPTICS, 1997, 36 (19) :4613-4619

[6] Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma [J].

Gannot, G ;

Gannot, I ;

Vered, H ;

Buchner, A ;

Keisari, Y .

BRITISH JOURNAL OF CANCER, 2002, 86 (09) :1444-1448

[7] Laser activated fluorescence measurements and morphological features:: an in vivo study of clearance time of fluorescein isothiocyanate tagged cell markers [J].

Gannot, I ;

Gannot, G ;

Garashi, A ;

Gandjbakhche, A ;

Buchner, A ;

Keisari, Y .

JOURNAL OF BIOMEDICAL OPTICS, 2002, 7 (01) :14-19

[8] In vivo quantitative three-dimensional localization of tumor labeled with exogenous specific fluorescence markers [J].

Gannot, I ;

Garashi, A ;

Gannot, G ;

Chernomordik, V ;

Gandjbakhche, A .

APPLIED OPTICS, 2003, 42 (16) :3073-3080

[9] In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green [J].

Intes, X ;

Ripoll, J ;

Chen, Y ;

Nioka, S ;

Yodh, AG ;

Chance, B .

MEDICAL PHYSICS, 2003, 30 (06) :1039-1047

[10] Small animal imaging: current technology and perspectives for oncological imaging [J].

Lewis, JS ;

Achilefu, S ;

Garbow, JR ;

Laforest, R ;

Welch, MJ .

EUROPEAN JOURNAL OF CANCER, 2002, 38 (16) :2173-2188

← 1 2 →