Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus: Hisayama study

被引：26

作者：

Song, Jingyu ^{[1
]}

Sumiyoshi, Shinji ^{[1
]}

Nakashima, Yutaka ^{[3
]}

Doi, Yasufumi ^{[2
]}

Iida, Mitsuo ^{[2
]}

Kiyohara, Yutaka ^{[2
]}

Sueishi, Katsuo ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Pathol, Higashi Ku, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Med, Fukuoka 8128582, Japan

[3] Fukuoka Red Cross Hosp, Div Pathol, Fukuoka, Japan

来源：

ATHEROSCLEROSIS | 2009年 / 202卷 / 02期

关键词：

Heme oxygenase-1; Human coronary artery; Atherosclerosis; Diabetes mellitus; Immunohistochemistry; EXPRESSION; ANGIOGENESIS; DISEASE; NEOVASCULARIZATION; PROGRESSION; INTIMAS; LESIONS;

D O I：

10.1016/j.atherosclerosis.2008.05.057

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Few studies regarding the topographical expression of heme oxygenase-1 (HO-1) and its pathophysiological role in human coronary atherosclerotic lesions, particularly in relation to type 2 diabetes mellitus (DM) and intimal angiogenesis, have been reported. HO-I expression was immunohistochemically examined in 312 tissue blocks of coronary arteries obtained from 53 Japanese autopsy cases in Hisayama cohort study that included 19 diabetic subjects and 34 age- and sex-matched non-diabetic subjects (56-93 years old, mean +/- S.D.: 73 +/- 10). The HO-1 was ubiquitously distributed in atherosclerotic intima, and was mainly expressed by macrophages and endothelial cells, and partly by smooth muscle cells. The prevalence of HO-1 expression increased as the lesion type (as classified by the American Heart Association (AHA) Committee) and stenotic grade progressed (p<0.0001), and was significantly higher in diabetic than in non-diabetic subjects (p<0.01). This HO-1 overexpression was associated with greater CD-68-positive macrophage infiltration (p=0.005). Interestingly, the distribution of HO-1-positive cells was accentuated in coronary atherosclerotic lesions with intimal microvessels in diabetic subjects (p<0.05), particularly those with hypercholesterolemia (p<0.05), and was preferentially distributed in the shoulder region of atherosclerotic lesion type IV in the AHA classification (p<0.01). In conclusion, HO-1 expression was distributed in overall human coronary atherosclerotic lesions, particularly in diabetic subjects, indicating that HO-1 expression is intimately associated with atherogenesis and may play an important role as ail adaptive molecule in the inflammatory-repair process. The association of HO-1 overexpression with a greater extent of intraplaque angiogenesis suggests a multi-faceted role for HO-1 in modulating the progression of atherosclerosis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：573 / 581

页数：9

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