Determination of the drug naphazoline in pharmaceutical preparations by heavy atom-induced room-temperature phosphorescence

被引：24

作者：

Gutiérrez, AF ^{[1
]}

Carretero, AS ^{[1
]}

Díaz, BC ^{[1
]}

Blanco, CC ^{[1
]}

机构：

[1] Univ Granada, Fac Sci, Dept Analyt Chem, E-18071 Granada, Spain

来源：

APPLIED SPECTROSCOPY | 1999年 / 53卷 / 06期

关键词：

pharmaceutical analysis; naphazoline; heavy atom induced (HAI); room-temperature phosphorescence (RTP);

D O I：

10.1366/0003702991947199

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

A simple, selective, and sensitive heavy atom-induced room-temperature phosphorimetric method (HAI-RTP) is described for the determination of naphazoline (NPZ) in pharmaceutical preparations. The phosphorescence signals are a consequence of intermolecular protection when analytes are, exclusively, in the presence of a heavy atom salt and sodium sulfite as an oxygen scavenger to minimize RTP quenching. This variable selection constitutes the basis of the HAI-RTP method for the determination of naphazoline (detection limit 43.5 ng/mL; 2.39% relative standard deviation at 500 ng/mL), The method has been applied to the analysis of pharmaceutical preparations.

引用

页码：741 / 744

页数：4

共 30 条

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