Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain

被引：57

作者：

Johansson, Emily M. ^{[1
]}

Reyes-Irisarri, Elisabeth ^{[1
]}

Mengod, Guadalupe ^{[1
]}

机构：

[1] CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Neurochem & Neuropharmacol,CIBERNED, Barcelona 08036, Spain

来源：

NEUROSCIENCE LETTERS | 2012年 / 525卷 / 01期

关键词：

Cyclic AMP; In situ hybridization; PDE4; PDE7; Rat; Mouse; Neuroanatomy; IN-SITU HYBRIDIZATION; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; DIFFERENTIAL DISTRIBUTION; SPLICE VARIANTS; EXPRESSION; INHIBITORS; ISOFORMS; DISEASE; ENCEPHALOMYELITIS; SCHIZOPHRENIA;

D O I：

10.1016/j.neulet.2012.07.050

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

There are eleven families of phosphodiesterases that regulate cellular levels of cyclic nucleotides by degradation of cAMP or cGMP. Knowledge of the expression sites of different PDE genes in brain is of special importance for studies on development of specific inhibitors considering that, for example, PDE4 inhibitor treatments exhibit profound anti-inflammatory effects. To address possible species differences we examined the expression of mRNAs coding for the cAMP specific PDE4 and PDE7 families since inhibitors have been used in clinic for schizophrenia, mood disorders, cognition and inflammatory diseases treatment. We have compared the expression of these PDEs in mouse brain by in situ hybridization histochemistry in comparison with rat brain and found that their neuroanatomical distribution differs in a few areas. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

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