Synthesis of novel antifungal phthalides produced by a wheat rhizosphere fungus

被引：16

作者：

Katoh, Naoto ^{[1
]}

Nakahata, Takashi ^{[1
]}

Kuwahara, Shigefumi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Lab Appl Bioorgan Chem, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

TETRAHEDRON | 2008年 / 64卷 / 38期

关键词：

phthalide; take-all; total synthesis; Alder-Rickert reaction;

D O I：

10.1016/j.tet.2008.07.023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two antifungal phthalides produced by a wheat rhizosphere fungus have been synthesized using the Alder-Rickert reaction to construct their common isobenzofuranone core structure. The absolute configuration of one of the two phthalides has been determined to be S by synthesizing its (S)- and (R)-enantiomer and comparing their optical rotations with that of the natural product. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：9073 / 9077

页数：5

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