Differences in rates of glycation (glycation index) may significantly affect individual HbA1c results in type 1 diabetes

被引:52
作者
Hudson, PR [1 ]
Child, DF
Jones, H
Williams, CP
机构
[1] Wrexham Maelor Hosp, Dept Med Biochem, Wrexham LL13 7TD, England
[2] Wrexham Maelor Hosp, Dept Diabet Med, Wrexham LL13 7TD, England
关键词
analysis of covariance; diabetes monitoring; inter-individual differences; post-transcriptional glycation;
D O I
10.1177/000456329903600408
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Ten type I diabetic patients recorded their daily home blood glucose values, pre- and post-prandially, for 12 weeks. Blood was collected weekly for HbA(1c) and total haemoglobin measurement. A rolling 28-day mean of all blood glucose values and a glycation index (the ratio of the HbA(1c) to the rolling mean blood glucose) were calculated. In the pooled patients' data, there was a large scatter of results about the HbA(1c) versus mean blood glucose regression line. There was less variation in the results of individual patients. The glycation indices showed marked inter-individual variation, and in 60% of patients there was an inverse relationship between glycation index and mean blood glucose, suggesting a non-linear relationship between mean blood glucose and HbA(1c). Patients should be monitored on the basis of their own previous results, and in some patients blood HbA(1c) may be a less sensitive index of mean blood glucose concentration at higher glucose levels.
引用
收藏
页码:451 / 459
页数:9
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