Getting the genome in shape: the formation of loops, domains and compartments

被引：79

作者：

Bouwman, Britta A. M.

de Laat, Wouter ^{[1
]}

机构：

[1] Hubrecht Inst KNAW, NL-3584 CT Utrecht, Netherlands

来源：

GENOME BIOLOGY | 2015年 / 16卷

基金：

欧洲研究理事会;

关键词：

EMBRYONIC STEM-CELLS; BETA-GLOBIN LOCUS; CHROMOSOME CONFORMATION CAPTURE; NUCLEAR LAMINA INTERACTIONS; ORDER CHROMATIN-STRUCTURE; LONG-RANGE INTERACTIONS; GENE-EXPRESSION; MITOTIC CHROMATIN; TRANSCRIPTION REGULATION; HYPERSENSITIVE SITES;

D O I：

10.1186/s13059-015-0730-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

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页数：9

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