A perspective on inversin

被引：32

作者：

Eley, L

Turnpenny, L

Yates, LM

Craighead, AS

Morgan, D

Whistler, C

Goodship, JA

Strachan, T

机构：

[1] Univ Newcastle, Int Ctr Life, Inst Human Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[2] Univ Southampton, Southampton Gen Hosp, Div Human Genet, Southampton SO16 6YD, Hants, England

来源：

CELL BIOLOGY INTERNATIONAL | 2004年 / 28卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

inversin; situs inversus; primary cilia; nephronopthisis;

D O I：

10.1016/j.cellbi.2003.11.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left-right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left-right axis and renal function remains to be elucidated. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：119 / 124

页数：6

共 26 条

[1] Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice [J].