Protective role of TNF-alpha in respiratory syncytial virus infection in vitro and in vivo

被引：53

作者：

Neuzil, KM ^{[1
]}

Tang, YW ^{[1
]}

Graham, BS ^{[1
]}

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,NASHVILLE,TN 37232

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 1996年 / 311卷 / 05期

关键词：

respiratory syncytial virus; tumor necrosis factor-alpha; murine model; immunopathogenesis;

D O I：

10.1097/00000441-199605000-00001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Respiratory syncytial virus (RSV) infection causes substantial morbidity in young children and immunocompromised adults, yet its pathogenesis is poorly understood. Because the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) may be important in host response to viral infection, HEp-2 cells were treated with TNF-alpha and mice were given TNF-alpha antibody before RSV infection. Pretreatment of HEp-2 cells with TNF-alpha inhibited RSV replication as determined by cytopathic effect. Respiratory syncytial virus-infected BALB/c mice treated with antibody to TNF-alpha had greater maximal weight loss and slower recovery time than control mice, These results suggest a protective role for TNF-alpha in RSV infection.

引用

页码：201 / 204

页数：4

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