Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells
被引:85
作者:
Agarwal, S.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
Yale Univ, Dept Internal Med, Sect Med Oncol, Yale Comprehens Canc Ctr,Sch Med, New Haven, CT 06520 USAYale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
Agarwal, S.
[1
,2
]
Zerillo, C.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Internal Med, Sect Med Oncol, Yale Comprehens Canc Ctr,Sch Med, New Haven, CT 06520 USAYale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
Zerillo, C.
[2
]
Kolmakova, J.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USAYale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
Kolmakova, J.
[1
]
Christensen, J. G.
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Global Res & Dev, Dept Res Pharmacol, La Jolla, CA 92121 USAYale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
Christensen, J. G.
[3
]
Harris, L. N.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Internal Med, Sect Med Oncol, Yale Comprehens Canc Ctr,Sch Med, New Haven, CT 06520 USAYale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
Harris, L. N.
[2
]
Rimm, D. L.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USAYale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
Rimm, D. L.
[1
]
DiGiovanna, M. P.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Internal Med, Sect Med Oncol, Yale Comprehens Canc Ctr,Sch Med, New Haven, CT 06520 USAYale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
DiGiovanna, M. P.
[2
]
Stern, D. F.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USAYale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
Stern, D. F.
[1
]
机构:
[1] Yale Univ, Dept Pathol, Sch Med, New Haven, CT 06520 USA
[2] Yale Univ, Dept Internal Med, Sect Med Oncol, Yale Comprehens Canc Ctr,Sch Med, New Haven, CT 06520 USA
[3] Pfizer Global Res & Dev, Dept Res Pharmacol, La Jolla, CA 92121 USA
There is a pressing need to identify new drug targets and novel approaches for treatment of non-small-cell lung carcinoma (NSCLC). Members of the epidermal growth factor receptor (EGFR) and Met receptor families have been identified as important molecular targets for NSCLC. Two EGFR tyrosine kinase inhibitors (TKIs; erlotinib and gefitinib) are in current clinical use, but a majority of patients do not respond to these targeted therapies. We used receptor TK (RTK) capture arrays to identify receptors active in NSCLC cell lines. As Met and ErbBs were active, we explored the potential therapeutic advantage of combined targeting of Met with ErbB receptor family inhibitors for treatment of NSCLC. We found that Met physically interacts with both EGFR and Her2 in a NSCLC cell line with overexpression/overactivation of Met. Combined use of a dual EGFR/Her2 inhibitor with a Met inhibitor yields maximal growth inhibition compared with the use of EGFR and/or Met inhibitors. This suggests that simultaneous inhibition of multiple RTKs may be needed to effectively abrogate tumour cell growth. Phosphoproteomic analysis by RTK capture arrays may be a valuable tool for identifying the subset of tumours with functional receptor activation, regardless of mechanism.
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Bean, James
;
Brennan, Cameron
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Neurosurg, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Brennan, Cameron
;
Shih, Jin-Yuan
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 100, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Shih, Jin-Yuan
;
Riely, Gregory
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Surg Serv, Div Solid Tumor Oncol, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Riely, Gregory
;
Viale, Agnes
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Genom Core Lab, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Viale, Agnes
;
Wang, Lu
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Wang, Lu
;
Chitale, Dhananjay
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Chitale, Dhananjay
;
Motoi, Noriko
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Japanese Fdn Canc Res, Dept Pathol, Tokyo 1358550, JapanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Motoi, Noriko
;
Szoke, Janos
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Natl Inst Oncol, Dept Mol Pathol, Budapest, HungaryMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Szoke, Janos
;
Broderick, Stephen
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Neurosurg, Thorac Surg Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Broderick, Stephen
;
Balak, Marissa
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Balak, Marissa
;
Chang, Wen-Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Chang Gung Mem Hosp, Dept Hematol Oncol, Tao Yuan 333, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Chang, Wen-Cheng
;
Yu, Chong-Jen
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 100, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Yu, Chong-Jen
;
Gazdar, Adi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr, Dallas, TX 75390 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Gazdar, Adi
;
Pass, Harvey
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Med Ctr, Dept Cardiothorac Surg, New York, NY 10016 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Pass, Harvey
;
Rusch, Valerie
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Neurosurg, Thorac Surg Serv, New York, NY 10021 USA
Natl Inst Oncol, Dept Mol Pathol, Budapest, HungaryMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Rusch, Valerie
;
Gerald, William
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Gerald, William
;
Huang, Shiu-Feng
论文数: 0引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Div Mol & Genom Med, Miaoli 350, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Huang, Shiu-Feng
;
Yang, Pan-Chyr
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 100, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Yang, Pan-Chyr
;
Miller, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Surg Serv, Div Solid Tumor Oncol, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Miller, Vincent
;
Ladany, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Ladany, Marc
;
Yang, Chih-Hsin
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Grad Inst Clin Med, Dept Oncol, Taipei 100, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Yang, Chih-Hsin
;
Pao, William
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Surg Serv, Div Solid Tumor Oncol, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Bean, James
;
Brennan, Cameron
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Neurosurg, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Brennan, Cameron
;
Shih, Jin-Yuan
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 100, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Shih, Jin-Yuan
;
Riely, Gregory
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Surg Serv, Div Solid Tumor Oncol, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Riely, Gregory
;
Viale, Agnes
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Genom Core Lab, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Viale, Agnes
;
Wang, Lu
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Wang, Lu
;
Chitale, Dhananjay
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Chitale, Dhananjay
;
Motoi, Noriko
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Japanese Fdn Canc Res, Dept Pathol, Tokyo 1358550, JapanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Motoi, Noriko
;
Szoke, Janos
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Natl Inst Oncol, Dept Mol Pathol, Budapest, HungaryMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Szoke, Janos
;
Broderick, Stephen
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Neurosurg, Thorac Surg Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Broderick, Stephen
;
Balak, Marissa
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Balak, Marissa
;
Chang, Wen-Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Chang Gung Mem Hosp, Dept Hematol Oncol, Tao Yuan 333, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Chang, Wen-Cheng
;
Yu, Chong-Jen
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 100, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Yu, Chong-Jen
;
Gazdar, Adi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr, Dallas, TX 75390 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Gazdar, Adi
;
Pass, Harvey
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Med Ctr, Dept Cardiothorac Surg, New York, NY 10016 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Pass, Harvey
;
Rusch, Valerie
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Neurosurg, Thorac Surg Serv, New York, NY 10021 USA
Natl Inst Oncol, Dept Mol Pathol, Budapest, HungaryMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Rusch, Valerie
;
Gerald, William
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Gerald, William
;
Huang, Shiu-Feng
论文数: 0引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Div Mol & Genom Med, Miaoli 350, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Huang, Shiu-Feng
;
Yang, Pan-Chyr
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 100, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Yang, Pan-Chyr
;
Miller, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Surg Serv, Div Solid Tumor Oncol, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Miller, Vincent
;
Ladany, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Ladany, Marc
;
Yang, Chih-Hsin
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Grad Inst Clin Med, Dept Oncol, Taipei 100, TaiwanMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Yang, Chih-Hsin
;
Pao, William
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Med, Thorac Surg Serv, Div Solid Tumor Oncol, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA