TMC-66, a new endothelin converting enzyme inhibitor produced by Streptomyces sp A5008

被引：14

作者：

Asai, Y ^{[1
]}

Nonaka, N ^{[1
]}

Suzuki, SI ^{[1
]}

Nishio, M ^{[1
]}

Takahashi, K ^{[1
]}

Shima, H ^{[1
]}

Ohmori, K ^{[1
]}

Ohnuki, T ^{[1
]}

Komatsubara, S ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 07期

关键词：

D O I：

10.7164/antibiotics.52.607

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated from the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzo[a]naphthacenequinone class of antibiotics. TMC-66 had a highly selective inhibitory activity for ECE with an IC50 value of 2.9 mu M. Taxonomy of the producing strain is also described.

引用

页码：607 / 612

页数：6

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