Maternal Neutralizing Antibody and Transmission of Hepatitis C Virus to Infants

被引：17

作者：

Dowd, Kimberly A. ^{[1
]}

Hershow, Ronald C. ^{[4
]}

Yawetz, Sigal ^{[5
,6
]}

LaRussa, Philip ^{[7
]}

Diaz, Clemente ^{[9
]}

Landesman, Sheldon H. ^{[8
]}

Paul, Mary E. ^{[10
]}

Read, Jennifer S. ^{[3
]}

Lu, Ming

Thomas, David L. ^{[1
,2
]}

Netski, Dale M. ^{[1
]}

Ray, Stuart C. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Med Inst, Dept Epidemiol, Baltimore, MD 21205 USA

[3] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Adolescent & Maternal AIDS Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD USA

[4] Univ Illinois, Sch Publ Hlth, Chicago, IL USA

[5] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Boston, MA USA

[7] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

[8] Brookdale Hosp, Dept Med, Brooklyn, NY USA

[9] Univ Puerto Rico, San Juan, PR 00936 USA

[10] Baylor Coll Med, Houston, TX 77030 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1086/593067

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To determine whether lower levels of hepatitis C virus (HCV) specific neutralizing antibodies (nAb) are associated with an increased risk of mother-to-child transmission (MTCT) of HCV, HCV nAb titers were assessed in 63 mothers coinfected with HCV and human immunodeficiency virus (HIV) type 1. Of the mothers, 16 transmitted HCV to their infant, but no difference was detected between the ability of maternal plasma from transmitters and nontransmitters to neutralize heterologous HCV pseudoparticles (median nAb titer, 1: 125 vs. 1: 100; P = .23). In the setting of HIV/HCV coinfection, we found no evidence that HCV nAbs are associated with the prevention of MTCT of HCV.

引用

页码：1651 / 1655

页数：5

共 15 条

[1] In vitro assay for neutralizing antibody to hepatitis C virus:: Evidence for broadly conserved neutralization epitopes [J].

Bartosch, B ;

Bukh, J ;

Meunier, JC ;

Granier, C ;

Engle, RE ;

Blackwelder, WC ;

Emerson, SU ;

Cosset, FL ;

Purcell, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) :14199-14204

[2] Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes [J].

Bartosch, B ;

Dubuisson, J ;

Cosset, FL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (05) :633-642

[3] Cellular immune selection with hepatitis C virus persistence in humans [J].

Cox, AL ;

Mosbruger, T ;

Mao, Q ;

Liu, Z ;

Wang, XH ;

Yang, HC ;

Sidney, J ;

Sette, A ;

Pardoll, D ;

Thomas, DL ;

Ray, SC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (11) :1741-1752

[4] Increased vertical transmission of human immunodeficiency virus from hepatitis C virus-coinfected mothers [J].

Hershow, RC ;

Riester, KA ;

Lew, J ;

Quinn, TC ;

Mofenson, LM ;

Davenny, K ;

Landesman, S ;

Cotton, D ;

Hanson, IC ;

Hillyer, GV ;

Tang, HB ;

Thomas, DL .

JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (02) :414-420

[5] Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles [J].

Hsu, M ;

Zhang, J ;

Flint, M ;

Logvinoff, C ;

Cheng-Mayer, C ;

Rice, CM ;

McKeating, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (12) :7271-7276

[6] Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection [J].

Lavillette, D ;

Morice, Y ;

Germanidis, G ;

Donot, P ;

Soulier, A ;

Pagkalos, E ;

Sakellariou, G ;

Intrator, L ;

Bartosch, B ;

Pawlotsky, JM ;

Cosset, FL .

JOURNAL OF VIROLOGY, 2005, 79 (10) :6023-6034

[7] Neutralizing antibody response during acute and chronic hepatitis C virus infection [J].

Logvinoff, C ;

Major, ME ;

Oldach, D ;

Heyward, S ;

Talal, A ;

Balfe, P ;

Feinstone, SM ;

Alter, H ;

Rice, CM ;

McKeating, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (27) :10149-10154

[8] Risk factors for perinatal transmission of hepatitis C virus (HCV) and the natural history of HCV infection acquired in infancy [J].

Mast, EE ;

Hwang, LY ;

Seto, DSY ;

Nolte, FS ;

Nainan, OV ;

Wurtzel, H ;

Alter, MJ .

JOURNAL OF INFECTIOUS DISEASES, 2005, 192 (11) :1880-1889

[9] Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1 [J].

Meunier, JC ;

Engle, RE ;

Faulk, K ;

Zhao, M ;

Bartosch, B ;

Alter, H ;

Emerson, SU ;

Cosset, FL ;

Purcell, RH ;

Bukh, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (12) :4560-4565

[10] CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection [J].

Netski, Dale M. ;

Mosbruger, Tim ;

Astemborski, Jacquie ;

Mehta, Shruti H. ;

Thomas, David L. ;

Cox, Andrea L. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (06) :857-863

← 1 2 →