Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo

被引：94

作者：

Hsu, M

Muchova, L

Morioka, I

Wong, RJ ^{[1
]}

Schröder, H

Stevenson, DK

机构：

[1] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

[2] Univ Halle Wittenberg, Dept Pharmacol & Toxicol, Sch Pharm, D-4010 Halle, Saale, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 343卷 / 03期

关键词：

antioxidants; lipids; lipoproteins; carbon monoxide; imaging;

D O I：

10.1016/j.bbrc.2006.03.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heme oxygenase-1 (HO-1) plays a central role in antioxidant and anti-inflammatory actions, which may be mediated through its formation of biliverdin/bilirubin and carbon monoxide. HMG-CoA reductase inhibitors (statins) induce in vitro HO-1 expression and are reported to have pleiotropic benefits that reduce oxidative stress in the vasculature. We characterized the effects of statins on in vivo HO-1 expression in various extravascular tissues: liver, lung, brain, and heart. Adult mice were orally administered simvastatin, lovastatin, atorvastatin, or rosuvastatin. HO activity significantly increased in a statin- and tissue-specific manner, with all statins increasing heart and lung activity within 24 h. Significant elevations of HO-1 protein and mRNA were also observed in heart and lung after atorvastatin treatment. We conclude that in vivo HO-1 induction is statin- and tissue-specific. Through this pathway, statins may confer antioxidant and anti-inflammatory actions in the vasculature and extravascular systems. (c) 2006 Elsevier Inc. All rights reserved.

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页码：738 / 744

页数：7

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