Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa

被引:42
作者
Klimek-Tomczak, K
Mikula, M
Dzwonek, A
Paziewska, A
Karczmarski, J
Hennig, E
Bujnicki, JM
Bragoszewski, P
Denisenko, O
Bomsztyk, K
Ostrowski, J
机构
[1] Med Ctr Postgrad Educ, Dept Gastroenterol, PL-02781 Warsaw, Poland
[2] Marie Curie Sklodowska Mem Canc Ctr, PL-02781 Warsaw, Poland
[3] Inst Oncol, PL-02781 Warsaw, Poland
[4] Int Inst Mol & Cell Biol, Lab Bioinformat & Prot Engn, PL-02109 Warsaw, Poland
[5] Univ Washington, UW Med Lake Union, Dept Med, Seattle, WA 98109 USA
关键词
hnRNP K protein; RNA editing; colorectal cancer; phosphorylation;
D O I
10.1038/sj.bjc.6602938
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The heterogeneous nuclear ribonucleoprotein K (hnRNP K) protein is an RNA-binding protein involved in many processes that compose gene expression. K protein is upregulated in the malignant processes and has been shown to modulate the expression of genes involved in mitogenic responses and tumorigenesis. To explore the possibility that there are alternative isoforms of K protein expressed in colon cancer, we amplified and sequenced K protein mRNA that was isolated from colorectal cancers as well as from normal tissues surrounding the tumours. Sequencing revealed a single G-to-A base substitution at position 274 that was found in tumours and surrounding mucosa, but not in individuals that had no colorectal tumour. This substitution most likely reflects an RNA editing event because it was not found in the corresponding genomic DNAs. Sequencing of RNA from normal colonic mucosa of patients with prior resection of colorectal cancer revealed only the wild-type K protein transcript, indicating that G274A isoform is tumour related. To our knowledge, this is the first example of an RNA editing event in cancer and its surrounding tissue, a finding that may offer a new diagnostic and treatment marker.
引用
收藏
页码:586 / 592
页数:7
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